Requesting Cell-lines : List of Available Leukemia Lines

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Investigators may request up to 3 cell lines (cumulative overall requests) with minimal paper work. Between 3 and 10 lines requires justification and local review and >10 lines requires a formal application and approval by the appropriate COG committee.

The prioritization of how material is distributed will be determined by the COG Disease Committees and the COG Biology and Translational Research Committee.

Some previously published cell lines, with originating investigator approval, will be characterized by the COG Cell Culture and Xenograft Repository laboratories, and made available through this web site.

Questions about the Cell Culture and Xenograft Repository can be directed to CellRequest@cogcell.org.

As of February 2011, a revised MTA was finalized to encompass most concerns that were raised in the past. The MTA is final and no changes will be possible. If you still have questions regarding the MTA, you can email CellLineInfo@cogcell.org for clarification.

Children's Oncology Group Cell Culture and Xenograft Repository
Download the Cell Culture or Xenograft Transfer Agreement (Open Distribution List MTA) in Adobe PDF format.

Print the form, fill in your request, sign it, and either scan it to PDF format for sending to us (using the upload button on the cell request form), or fax it to 806-743-2691.

Please contact CellLineInfo@cogcell.org if you are requesting cell lines that are not currently on the Open Distribution List.

Requesting Leukemia Cell Lines

Select the cell lines wanted (requesting > 3 lines requires protocol approval) :

Select by clicking on the checkbox for the cell lines you want.

To deselect, just click on the checkbox a second time.

Please visit the COGcell.org website frequently, as cell line data is continually being updated and new cell lines are added.

All cell lines were established in 20% O2 unless otherwise noted. Cell lines ending in "h" designates cell line was established in hypoxic conditions (5% O2 tension).

Request	Cell Line	Disease	Diagnosis	Gender	Age (Years)	Phase of Therapy¹	Site of Specimen	DT⁵ (hours)	References
	COG-LL-317^*	Leukemia	T-cell ALL	M	1.7	PD	Bone marrow	30-40	26,27,28,49, PPTP
	COG-LL-317h^*	Leukemia	T-cell ALL	M	1.7	PD	Bone marrow	19-20	26,27,49, PPTP
	COG-LL-319h	Leukemia	Pre-B ALL	F	13	Dx	Bone marrow	50-62	26,27,28,49, PPTP
	COG-LL-329h	Leukemia	T-cell ALL			Dx	Bone marrow		28
	COG-LL-332h	Leukemia	T-cell ALL	M	10	PD	Bone marrow	30-34	28,49
	COG-LL-355h	Leukemia	Pre-B ALL			Dx	Bone marrow		28
	COG-LL-356h	Leukemia	Pre-B ALL			Dx	Bone marrow		28
	COG-LL-384h	Leukemia	T-cell ALL			PD	Bone marrow		28

¹ - Phase of therapy for the patient at the time the specimen used to derive the cell line was obtained
Dx (Diagnosis): cell lines derived from samples of patients prior to treatment
PD (Progressive Disease): cell lines derived from samples of patients who relapsed after chemotherapy
PD-BMT: cell lines derived from samples of patients who relapsed after chemotherapy and bone marrow transplantation
PD-PM: cell lines derived from samples of post-mortem patients who relapsed after chemotherapy

⁵ - Doubling Time

For details on all the cell lines see:

Kang MH, Smith MA, Morton CL, Nino Keshelava N, Houghton PJ, Reynolds CP: National Cancer Institute Pediatric Preclinical Testing Program: Model description for in vitro cytotoxicity testing. Pediatr Blood Cancer 56:239-49, 2011.

^* - NCI PPTP Cell Lines

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Please provide the name of your courier (eg. FedEx, Airborne, UPS) if available:
(nb. Please do not specify DHL as we are not able to use DHL for shipments.)

Please provide your FedEx or other courier account number (if available):

If you are requesting more than 3 cell lines:
Who should review the proposal? (Please select one)

The Disease Committee (for requests of material of a single disease)

The Biology and Translational Research Committee (for requests of material from multiple diseases)

If you are requesting 3-10 cell lines, upload a < 1 page description of research and justification for the lines.

(PDF format only; maximum allowed file size is 2 megabytes)

If you are requesting more than 10 lines, upload a full COG biology specimen application form.

(PDF format only; maximum allowed file size is 2 megabytes)

Upload your COG Specimen Transfer Agreement:

(PDF format only; maximum allowed file size is 2 megabytes)

You can also FAX this form to 806-743-2691 if you have difficulty uploading it.

Do you have any special requests or comments? If so, please enter them here.