Children's Oncology Group Cell Culture and Xenograft Repository Website

Requesting Cell-lines : List of Available EFT Lines

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Investigators may request up to 3 cell lines (cumulative overall requests) with minimal paper work. Between 3 and 10 lines requires justification and local review and >10 lines requires a formal application and approval by the appropriate COG committee.

The prioritization of how material is distributed will be determined by the COG Disease Committees and the COG Biology and Translational Research Committee.

Some previously published cell lines, with originating investigator approval, will be characterized by the COG Cell Culture and Xenograft Repository laboratories, and made available through this web site.

Questions about the Cell Culture and Xenograft Repository can be directed to CellRequest@cogcell.org.

As of February 2011, a revised MTA was finalized to encompass most concerns that were raised in the past. The MTA is final and no changes will be possible. If you still have questions regarding the MTA, you can email CellLineInfo@cogcell.org for clarification.

Children's Oncology Group Cell Culture and Xenograft Repository
Download the Cell Culture or Xenograft Transfer Agreement (Open Distribution List MTA) in Adobe PDF format.

Print the form, fill in your request, sign it, and either scan it to PDF format for sending to us (using the upload button on the cell request form), or fax it to 806-743-2691.

Please contact CellLineInfo@cogcell.org if you are requesting cell lines that are not currently on the Open Distribution List.

Requesting EFT Cell Lines

Select the cell lines wanted (requesting > 3 lines requires protocol approval) :

Select by clicking on the checkbox for the cell lines you want.

To deselect, just click on the checkbox a second time.

To view a complete cell line description (origin, growth conditions, pictures, etc.), click on the cell line name to open a pdf data sheet to view and/or download.

To view a characterization table of the EFT cell lines, click here.

Please visit the COGcell.org website frequently, as cell line data is continually being updated and new cell lines are added.

Request	Cell Line	Disease	Diagnosis	Age (Years)	Phase of Therapy¹	EWS/FLI1 Status⁴	p53 Status³	DT⁵ (hours)	References
	CHLA-9^*	Ewing's Family of Tumors	PNET	14	Dx	FLI1	F	51	22,PPTP
	CHLA-10^*	Ewing's Family of Tumors	PNET	14	PD	FLI1	N	32	12,22,PPTP
	CHLA-25	Ewing's Family of Tumors	PNET	2.6	PD	ERG	N	99
	CHLA-32	Ewing's Family of Tumors	PNET	8.5	Dx	FLI1	F	26	22
	CHLA-258^*	Ewing's Family of Tumors	PNET	14	PD	FLI1	N	89	22,PPTP
	COG-E-352	Ewing's Family of Tumors	PNET	17	PD-PM	ERG	N	28	22,PPTP
	TC-32	Ewing's Family of Tumors	PNET	17	Dx	FLI1	N	24	3,6,22,24,25
	TC-71^*	Ewing's Family of Tumors	Ewing's Sarcoma	22	PD	FLI1	N	21	6,22,23,25, 47,PPTP
¹ - Phase of therapy for the patient at the time the specimen used to derive the cell line was obtained Dx (Diagnosis): cell lines derived from samples of patients prior to treatment PD (Progressive Disease): cell lines derived from samples of patients who relapsed after chemotherapy PD-BMT: cell lines derived from samples of patients who relapsed after chemotherapy and bone marrow transplantation PD-PM: cell lines derived from samples of post-mortem patients who relapsed after chemotherapy ³ - p53 gene function F: Functional N: Non-Functional ⁴ - EWS/FLI1 Status FLI1: friend leukemia insertion - chromosome 11, t(11;22) ERG: ets-related gene - chromosome 21, t(21;22) ⁵ - Doubling Time ^* - NCI PPTP Cell Lines For details on all the NCI PPTP cell lines see: Kang MH, Smith MA, Morton CL, Nino Keshelava N, Houghton PJ, Reynolds CP: National Cancer Institute Pediatric Preclinical Testing Program: Model description for in vitro cytotoxicity testing. Pediatr Blood Cancer 56:239-49, 2011.

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If you are requesting more than 3 cell lines,
Who should review the proposal? (Please select one)

The Disease Committee (for requests of material of a single disease)

The Biology and Translational Research Committee (for requests of material from multiple diseases)

If you are requesting 3-10 cell lines, upload a < 1 page description of research and justification for the lines.

(PDF format only; maximum allowed file size is 2 megabytes)

If you are requesting more than 10 lines, upload a full COG biology specimen application form.

(PDF format only; maximum allowed file size is 2 megabytes)

Upload your COG Specimen Transfer Agreement:

(PDF format only; maximum allowed file size is 2 megabytes)

You can also FAX this form to 806-743-2691 if you have difficulty uploading it.

Do you have any special requests or comments? If so, please enter them here.